Tret 10mg | Isotretinoin | ePharma
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Tret 10mg Capsule

Generic: Isotretinoin

Type: Capsule

Pack Size: 10 Pcs

Isotretinoin is indicated in severe forms of acne (such as nodular acne or acne with a risk of permanent scarring) that are resistant to full standard therapy with systemic antibodies and antiretroviral therapy. topical treatment.


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Discount Price: ৳ 480
MRP: ৳ 500 4% Off

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✅ Description:

Tret 10mg Capsule is a medication belonging to the retinoid class of drugs, which is a synthetic form of vitamin A. It is primarily used to treat a severe and stubborn form of acne known as nodular acne. Nodular acne is characterized by the presence of swollen, red, and tender lumps on the skin due to excessive oil production in skin cells. These acne nodules are larger and more severe than typical pimples.

The active ingredient in Tret 10mg Capsule is 'isotretinoin,' and it works through several mechanisms to effectively treat acne:

Reducing Sebum Production: Isotretinoin decreases the production of sebum, the skin's natural oil. It achieves this by reducing the activity and size of the sebaceous glands, which are responsible for producing sebum. By reducing sebum production, isotretinoin helps unblock pores and prevent the development of acne.

Killing Acne-Causing Bacteria: Isotretinoin helps kill the bacteria responsible for causing acne, further preventing the formation of new acne lesions.

It's crucial to take Tret 10mg Capsule exactly as prescribed by your doctor. The dosing frequency and duration will be determined based on your specific medical condition.

While using Tret 10mg Capsule, some individuals may experience side effects such as chapped lips, and dryness of the skin, eyes, nose, or lips. Most of these side effects are generally mild and do not require medical attention. They tend to improve over time. However, if these side effects persist or worsen, it's advisable to consult your doctor.

  • Inform your doctor if you are allergic to Tret 10mg Capsule or any other medications.
  • Do not use Tret 10mg Capsule if you are pregnant or breastfeeding, as it can have adverse effects on the baby.
  • If you experience symptoms of depression or have suicidal thoughts while taking Tret 10mg Capsule or after discontinuing treatment, consult a healthcare professional.
  • Avoid excessive sun exposure while using Tret 10mg Capsule, as it can make your skin more sensitive to sunlight and lead to sunburn. Use protective clothing and sunscreen when going outdoors to protect your skin.

Safety Advices


Alcohol
UNSAFE

Avoid consuming alcohol while taking Tret 10mg Capsule, as it may increase the risk of side effects. It is essential to inform your doctor if you have a history of alcohol use.


Pregnancy
CONSULT YOUR DOCTOR

Tret 10mg Capsule is contraindicated during pregnancy due to the risk of severe birth defects in the developing fetus. It is crucial to inform your doctor if you become pregnant while undergoing treatment with Tret 10mg Capsule or within one month after discontinuing the medication. Effective contraception must be used one month before starting the treatment, during the treatment course, and for one month after completing the treatment. Discuss suitable contraceptive methods with your healthcare provider.


Breastfeeding
CONSULT YOUR DOCTOR

Tret 10mg Capsule is not recommended for use in breastfeeding women as it may pass into breast milk. It is essential to consult your doctor before taking this medication if you are breastfeeding.


Driving
CAUTION

If you experience dizziness, drowsiness, or decreased night vision after taking Tret 10mg Capsule, it is advisable not to drive or operate machinery. These side effects can affect your ability to perform tasks that require concentration and clear vision.


Kidney
CAUTION

Use Tret 10mg Capsule with caution if you have kidney problems. It is advisable to consult your doctor before starting treatment.


Liver
CAUTION

Tret 10mg Capsule is not recommended for use in patients with liver disease. It is crucial to consult your doctor if you have any liver-related concerns before taking this medication.

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✔️ Uses of Tret 10mg Capsule
  • Used to treat severe forms of acne which has not improved after other anti-acne treatments in adults and children (older than 12 years of age)
✔️ How does Tret 10mg Capsule work?

Tret 10 works by reducing the production of sebum (natural skin oil) in the sebaceous glands, which helps prevent clogged pores and the formation of acne. It also has anti-inflammatory properties that can reduce redness and swelling associated with acne lesions.

✔️ Side Effects of Tret 10mg Capsule
  • Dry skin
  • Rash
  • Increased liver enzyme levels
  • Changes in skin color
  • Bleeding from nose
  • Scaling, burning, redness, and swelling of skin
✔️ Quick Suggestions:
  • Tret 10mg Capsule is used to treat severe acne which has not responded to any other treatments.
  • Take this capsule in the exact dose and duration as prescribed by the doctor.
  • Complete the entire course of treatment with this medicine as prescribed by your doctor. Do not miss any dose and do not take more than the prescribed dose.
  • Take these capsules with food to improve absorption and reduce the risk of stomach upset.
  • Inform your doctor if you are pregnant, planning on becoming pregnant, or breastfeeding before starting the Tret 10mg Capsule.
  • Also, inform your doctor about all other medicines that you take and your complete medical history.
  • Tret 10mg Capsule might make your skin more sensitive to sunlight, so apply sunscreen and wear protective clothing while going outside.
  • These capsules also cause dryness of the skin, lips, and eyes. Use a moisturizer and lip balm regularly and use eye drops if needed.
  • Drink plenty of water and fluids to keep yourself hydrated.
  • While using Tret 10mg Capsule avoid taking vitamin supplements containing vitamin A, as this might result in vitamin A toxicity.
  • Touching your face can spread bacteria and oils, which can worsen acne. Avoid picking, popping, or squeezing your pimples, as this can also lead to scarring.
  • Keep your skin clean by washing your face twice or thrice a day with a gentle cleanser.
✔️ Nodular Acne:

Nodular acne is a severe and painful form of acne that results from the overproduction of oil (sebum) in the skin's sebaceous glands. It is characterized by the presence of large, swollen, red, and tender nodules or lumps beneath the skin's surface. These nodules can be quite sizable, often comparable in size to pencil erasers or even larger.

The development of nodular acne is primarily attributed to several factors, including:

  • Excess Sebum Production: The sebaceous glands in the skin produce sebum, an oily substance that helps keep the skin moisturized. In nodular acne, these glands produce an excessive amount of sebum, leading to an accumulation of oil under the skin.
  • Sebum Inhibition: In nodular acne, sebum production is disrupted, and the excess oil cannot flow freely to the skin's surface. This blockage within the pores creates an ideal environment for the proliferation of acne-causing bacteria.
  • Bacterial Growth: The trapped sebum under the skin provides an excellent breeding ground for bacteria known as Propionibacterium acnes (P. acnes). These bacteria thrive in the clogged pores and contribute to the development of inflammation and infection.

Nodular acne lesions affect the deeper layers of the skin, making them more painful and harder to treat than milder forms of acne, such as whiteheads or blackheads. These nodules can appear on various parts of the body, including the face, back, chest, and neck.

If left untreated, nodular acne can have long-term consequences, including the formation of permanent scars. The symptoms of nodular acne typically include:

  • Long-lasting and painful blemishes.
  • Large, hard knots or nodules beneath the skin's surface.
  • Redness and inflammation around the affected areas.
  • Tenderness and discomfort in the affected regions.

Nodular acne can be emotionally distressing and physically uncomfortable. Effective treatment options, such as isotretinoin (found in medications like Tret 10mg Capsule), may be prescribed by healthcare providers to manage this severe form of acne and prevent scarring. It's essential to consult with a healthcare professional for an accurate diagnosis and personalized treatment plan if you suspect you have nodular acne or any other skin condition.

✔️ Pharmacology

Isotretinoin, a medication used to treat severe acne, exerts its effects through various mechanisms:

  • Altering Cell Cycle Progression and Differentiation: Isotretinoin affects the cell cycle, cell differentiation, and survival of skin cells. This alteration reduces the production of sebum (skin oil), preventing the clogging of pores and the growth of acne-causing bacteria.
  • Reducing Sebum Production: Both isotretinoin and its metabolite, 4oxoisotretinoin, significantly reduce the production of sebum. By decreasing sebum production, isotretinoin helps prevent pore blockage, a common factor in acne development.
  • Binding to Retinoic Acid Receptors: Unlike isotretinoin, which has little or no affinity for retinol-binding proteins (RBPs) and nuclear retinoic acid receptors (RARs), tretinoin and 4oxotretinoin bind to the RARγ receptor. This receptor interaction is thought to contribute to isotretinoin's effectiveness in treating acne.
  • Inducing Cell Apoptosis: Isotretinoin induces apoptosis (programmed cell death) in sebaceous gland cells, leading to decreased sebum production. By causing these cells to die off, isotretinoin helps reduce excess oil on the skin.
  • Reducing Hyperkeratosis: Isotretinoin also reduces the development of hyperkeratosis (excessive skin cell accumulation) by an unknown mechanism. This reduction in hyperkeratosis helps prevent the formation of acne lesions.
  • Modulating the Skin Microenvironment: Isotretinoin doesn't directly kill acne-causing bacteria but changes the microenvironment of the sebaceous glands to make it less favorable for bacterial growth.
  • Enhancing Immune Responses: Isotretinoin may boost the immune system's activity, helping the body fight against acne-causing factors.
  • Reducing Inflammation: Isotretinoin can alter the chemistry of immune cells called monocytes, potentially reducing inflammation associated with acne.

These complex actions of isotretinoin collectively contribute to its effectiveness in treating severe acne. It is a potent medication with significant benefits but also potential side effects, and it should be used under close medical supervision.

✔️ Dosage & Administration of
  • Take Tret 10 with food to enhance absorption.
  • It may take several weeks for improvements in acne symptoms to become noticeable.
  • Do not increase the dosage or frequency of application without your doctor's approval, as it won't make the treatment work faster and may increase side effects.
  • If you miss a dose, take it as soon as possible, but do not double the dose if it's close to your next scheduled dose.
✔️ Interaction

Tret 10mg Capsule, like many medications, can interact with other medicines, herbal preparations, supplements, and even certain food items. Here are some important interactions to be aware of:

  • 1. Vitamin A Supplements: Taking Tret 10mg Capsule along with vitamin A supplements can increase the risk of developing high levels of vitamin A in the body. This can lead to vitamin A toxicity, which can have adverse effects on health. It's essential to avoid taking Tret 10mg Capsule and vitamin A supplements concurrently.
  • 2. Tetracycline Antibiotics: The concurrent use of Tret 10mg Capsule and tetracycline antibiotics, often used to treat infections, can potentially lead to high blood pressure. It's advisable to avoid taking these medications together, and if they are both prescribed, close monitoring by a healthcare provider is essential.
  • 3. Other Topical Acne Medications: Using Tret 10mg Capsule in conjunction with other topical acne treatments like benzoyl peroxide, tazarotene, azelaic acid, or tretinoin may increase skin irritation and dryness. It's usually best to avoid using these products simultaneously unless specifically directed by a healthcare provider.
  • 4. Food Interactions: Tret 10mg Capsule do not typically have significant food interactions. However, it's advisable to take Tret 10mg Capsule with food to improve its absorption and reduce the risk of gastrointestinal side effects. Avoiding excessive consumption of vitamin A-rich foods while taking Tret 10mg Capsule is also recommended to prevent an overabundance of vitamin A in the body.
✔️ Contraindications

Isotretinoin, a medication used to treat severe acne, carries significant risks, particularly in relation to pregnancy. Here are the key contraindications and requirements for its safe use, especially in women of childbearing potential:

Contraindications:

  • Women of Childbearing Potential: Isotretinoin is contraindicated in women of childbearing potential unless all requirements for a pregnancy prevention program are met.
  • Hypersensitivity: The drug should not be used in patients with known hypersensitivity to isotretinoin or any of its components.
  • Hepatic Impairment: Isotretinoin is contraindicated in patients with hepatic (liver) impairment.
  • Excessively High Blood Lipid Levels: It should not be used in individuals with excessively high blood lipid levels.
  • Hypervitaminosis A: Patients with hypervitaminosis A (excessive vitamin A levels) are also contraindicated from using isotretinoin.
  • Concurrent Use with Tetracyclines: Isotretinoin should not be used concurrently with tetracycline antibiotics.
  • Pregnancy Prevention Program Conditions: For women of childbearing potential, a comprehensive pregnancy prevention program must be in place before starting isotretinoin treatment. These conditions include:
  • Understanding Teratogenic Risk: The patient should be aware of the teratogenic (birth defect-causing) risk associated with isotretinoin.
  • Monthly Follow-Up Visits: The patient should understand the need for rigorous monthly follow-up visits with their healthcare provider.
  • Effective, Uninterrupted Contraception: The patient should commit to using effective contraception for at least one month before starting isotretinoin, during treatment, and for one month after completing treatment. Ideally, at least two forms of contraception, including a barrier method, should be used.
  • Prompt Counseling in Case of Pregnancy Risk: The patient should understand the potential consequences of pregnancy while taking isotretinoin and agree to seek prompt counseling if there is any risk of pregnancy.
  • Pregnancy Testing: The patient should undergo pregnancy testing before, during, and five weeks after the end of isotretinoin treatment. The results of these tests should be documented.
  • Patient's Informed Consent: The patient should acknowledge and understand the potential risks and precautions associated with using isotretinoin.

These conditions also apply to women who may not be currently sexually active, unless the prescriber determines that there is no risk of pregnancy based on compelling reasons. Prescribers are responsible for ensuring that patients meet these pregnancy prevention conditions and are knowledgeable about them.

The strict requirements and contraindications associated with isotretinoin underscore its potential risks, especially related to pregnancy, and the importance of responsible and informed use under medical supervision.

✔️ Pregnancy & Lactation

Pregnancy is an absolute contraindication for the use of isotretinoin. If a pregnancy occurs despite strict precautions during isotretinoin treatment or within a month following treatment, there is a significant risk of severe birth defects in the developing fetus. These fetal anomalies associated with exposure to isotretinoin include:

  • Central Nervous System Abnormalities: These can involve conditions such as hydrocephalus, cerebellar malformations or abnormalities, and microcephaly.
  • Facial Dysmorphia: This can manifest as facial deformities.
  • Cleft Palate: A congenital condition characterized by a split or opening in the roof of the mouth.
  • External Ear Abnormalities: These can include the absence or underdevelopment of the external ear or auditory canal.
  • Ocular Abnormalities: Including microphthalmia, a condition where the eyes are abnormally small.
  • Cardiovascular Abnormalities: Such as congenital heart defects including tetralogy of Fallot, transposition of the great vessels, or septal abnormalities.
  • Abnormalities of Thymus and Parathyroid Glands: These can affect the development of the immune system and calcium regulation.

The risk of spontaneous abortion (miscarriage) also appears to be higher in pregnant women exposed to isotretinoin.

If a woman becomes pregnant while undergoing isotretinoin treatment, it is imperative to discontinue the treatment immediately and seek guidance from a specialist or experienced teratologist for evaluation and advice regarding the pregnancy. Early intervention is crucial to assess and manage potential risks to the developing fetus.

Furthermore, isotretinoin is lipophilic, meaning it readily passes into breast milk. Due to the potential for adverse effects on infants exposed to breast milk containing isotretinoin, its use is strictly contraindicated in nursing mothers. This precaution is taken to protect the health and safety of the nursing infant.

In summary, the use of isotretinoin requires strict adherence to safety measures to prevent pregnancy, as any exposure during pregnancy can lead to severe birth defects. Additionally, nursing mothers should not use isotretinoin to avoid potential harm to their infants. These precautions underscore the importance of responsible and informed use of this medication.

✔️ Precautions & Warnings
  • Tret 10 can make the skin more sensitive to sunlight, so use sun protection measures and limit sun exposure.
  • Stay hydrated and use a moisturizer to counteract dryness.
  • Avoid waxing or laser treatments while using Tret 10, as it can make the skin more fragile.
  • It is not recommended for use during pregnancy, and women of childbearing age should use effective contraception while taking it.
  • Tret 10 can affect blood lipid levels, so your doctor may monitor these during treatment.
  • If you experience severe side effects like hearing impairment, abdominal pain, rectal bleeding, or severe diarrhea, contact your doctor.
✔️ Storage Conditions
  • Store Tret 10mg Capsule below 25°C in a clean and dry place, protected from moisture, sunlight, and heat.
  • Keep the medicine away from children and pets.
  • You should not use this medicine after the expiry date.
  • Do not use this medicine if you notice that the pack is damaged or shows signs of tampering.
Frequently Asked Questions (FAQ)

No

No

According to some studies, menstrual irregularity was observed during treatment follow-ups. Consult your doctor if you experience irregularity in your periods during treatment with ISOTROIN 20 CAPSULE.

"Avoid Cosmetic Procedures while on Tret 10mg Capsule.

Tret 10mg Capsule works by decreasing the oil in the skin and reducing the production of facial oil thus preventing acne.
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